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1

Biomarkers of eosinophilic inflammation in asthma

Loutsios, Chrystalla, Farahi, Neda, Porter, Linsey, Lok, Laurence SC, Peters, A Michael, Condliffe, Alison M, Chilvers, Edwin R

Journal:

Expert Review of Respiratory Medicine

Year:

2014

Language:

english

File:

PDF, 456 KB

english, 2014

2

The Neutrophil Life Cycle

Hidalgo, Andrés, Chilvers, Edwin R., Summers, Charlotte, Koenderman, Leo

Journal:

Trends in Immunology

Year:

2019

Language:

english

File:

PDF, 1.99 MB

english, 2019

3

The survival effect of TNF-α in human neutrophils is mediated via NF-κB-dependent IL-8 release

Andrew S. Cowburn, John Deighton, Sarah R. Walmsley, Edwin R. Chilvers

Journal:

European Journal of Immunology

Year:

2004

Language:

english

File:

PDF, 343 KB

english, 2004

4

Proteolytic action of duodenase is required to induce DNA synthesis in pulmonary artery fibroblasts : A role for phosphoinositide 3-kinase

Alan D. Pemberton, Tatyana S. Zamolodchikova, Cheryl L. Scudamore, Edwin R. Chilvers, Hugh R. P. Miller, Trevor R. Walker

Journal:

Year:

2002

Language:

english

File:

PDF, 417 KB

english, 2002

5

Quantification of disease activity in patients undergoing leucocyte scintigraphy for suspected inflammatory bowel disease

Heok K. Cheow, Demetrius D. Voutnis, John W. Evans, Katy R. Szczepura, E. Anna Swift, Nicholas J. Bird, Prina Ruparelia, Chandra K. Solanki, James R. Ballinger, Edwin R. Chilvers, Stephen J. Middleton

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Year:

2005

Language:

english

File:

PDF, 544 KB

english, 2005

6

Quantification of neutrophil migration into the lungs of patients with chronic obstructive pulmonary disease

Prina Ruparelia, Katherine R. Szczepura, Charlotte Summers, Chandra K. Solanki, Kottekkattu Balan, Paul Newbold, Diana Bilton, A. Michael Peters, Edwin R. Chilvers

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Year:

2011

Language:

english

File:

PDF, 487 KB

english, 2011

7

Pulmonary elimination rate of inhaled 99mTc-sestamibi radioaerosol is delayed in healthy cigarette smokers

Prina Ruparelia, Heok K. Cheow, John W. Evans, Leith Banney, Sonal Shankar, Katherine R. Szczepura, Anna E. Swift, James R. Ballinger, Neil G. Hartman, Edwin R. Chilvers, A. Michael Peters

Journal:

British Journal of Clinical Pharmacology

Year:

2008

Language:

english

File:

PDF, 435 KB

english, 2008

8

Measuring whole-body neutrophil redistribution using a dedicated whole-body counter and ultra-low doses of 111Indium

Katherine R. Szczepura, Prina Ruparelia, Chandra K. Solanki, Kottekkattu Balan, Paul Newbold, Charlotte Summers, Edwin R. Chilvers, A. Michael Peters

Journal:

European Journal of Clinical Investigation

Year:

2011

Language:

english

File:

PDF, 190 KB

english, 2011

9

Effect of priming on activation and localization of phospholipase D-1 in human neutrophils

Karen A. Cadwallader, Mohib Uddin, Alison M. Condliffe, Andrew S. Cowburn, Jessica F. White, Jeremy N. Skepper, Nicholas T. Ktistakis, Edwin R. Chilvers

Journal:

Year:

2004

Language:

english

File:

PDF, 455 KB

english, 2004

10

Gβγs and the Ras binding domain of p110γ are both important regulators of PI3Kγ signalling in neutrophils

Suire, Sabine, Condliffe, Alison M., Ferguson, G. John, Ellson, Chris D., Guillou, Hervé, Davidson, Keith, Welch, Heidi, Coadwell, John, Turner, Martin, Chilvers, Edwin R.

Journal:

Nature Cell Biology

Year:

2006

Language:

english

File:

PDF, 998 KB

english, 2006

11

Dissociation of lipopolysaccharide-mediated induction of nitric oxide synthase and inhibition of DNA synthesis in RAW 264.7 macrophages and rat aortic smooth muscle cells

Andrew Paul, Clare Bryant, Mark F. Lawson, Edwin R. Chilvers, Robin Plevin

Journal:

British Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 434 KB

english, 1997

12

Role of leukotrienes in the regulation of human granulocyte behaviour: dissociation between agonist-induced activation and retardation of apoptosis

Joanna Murray, Carol Ward, Joseph T O'Flaherty, Ian Dransfield, Christopher Haslett, Edwin R Chilvers, Adriano G Rossi

Journal:

British Journal of Pharmacology

Year:

2003

Language:

english

File:

PDF, 351 KB

english, 2003

13

Effect of temperature on muscarinic cholinoceptor-mediated phosphoinositide metabolism and tension generation in bovine tracheal smooth muscle

Edwin R. Chilvers, Mark A. Giembycz, R. A. John Challiss, Graham J. Offer, Stefan R. Nahorski

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

1994

Language:

english

File:

PDF, 800 KB

english, 1994

14

Changes in extracellular calcium within the physiological range influence receptor-mediated inositol phosphate responses in brain and tracheal smooth muscle slices

John G. Baird, Edwin R. Chilvers, Eleanor D. Kennedy, Stefan R. Nahorski

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

1989

Language:

english

File:

PDF, 598 KB

english, 1989

15

Phosphoinositide metabolism in airway smooth muscle

Edwin R. Chilvers, Barbara J. Lynch, R.A.John Challiss

Journal:

Pharmacology & Therapeutics

Year:

1994

Language:

english

File:

PDF, 2.18 MB

english, 1994

16

β-adrenoceptor induced inhibition of muscarinic receptor-stimulated phosphoinositide metabolism is agonist specific in bovine tracheal smooth muscle

Graham J. Offer, Edwin R. Chilvers, Stefan R. Nahorski

Journal:

European Journal of Pharmacology: Molecular Pharmacology

Year:

1991

Language:

english

File:

PDF, 647 KB

english, 1991

17

Thrombin induces DNA synthesis and phosphoinositide hydrolysis in airway smooth muscle by activation of distinct receptors

Trevor R. Walker, Karen A. Cadwallader, Alison MacKinnon, Edwin R. Chilvers

Journal:

Biochemical Pharmacology

Year:

2005

Language:

english

File:

PDF, 247 KB

english, 2005

18

Involvement of Mitogen-Activated Protein Kinase Homologues in the Regulation of Lipopolysaccharide-Mediated Induction of Cyclo-oxygenase-2 but not Nitric Oxide Synthase in RAW 264.7 Macrophages

Andrew Paul, Ana Cuenda, Clare E. Bryant, Jo Murray, Edwin R. Chilvers, Philip Cohen, Gwyn W. Gould, Robin Plevin

Journal:

Cellular Signalling

Year:

1999

Language:

english

File:

PDF, 393 KB

english, 1999

19

Stimulation by endothelin-1 of mitogen-activated protein kinases and DNA synthesis in bovine tracheal smooth muscle cells

Kevin Malarkey, Edwin R. Chilvers, Mark F. Lawson, Robin Plevin

Journal:

British Journal of Pharmacology

Year:

1995

Language:

english

File:

PDF, 1.67 MB

english, 1995

20

Effects of membrane depolarization and changes in intra- and extracellular calcium concentration on phosphoinositide hydrolysis in bovine tracheal smooth muscle

Edwin R. Chilvers, Barbara J. Lynch, Graham J. Offer, R.A.John Challiss

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 1.20 MB

english, 1994

21

Mass changes of inositol(1,4,5) trisphosphate in trachealis muscle following agonist stimulation

Edwin R. Chilvers, R.A. John Challiss, Peter J. Barnes, Stafan R. Nahorski

Journal:

European Journal of Pharmacology

Year:

1989

Language:

english

File:

PDF, 313 KB

english, 1989

22

Hypoxia prolongs neutrophil survival in vitro

Sharon Hannah, Kathryn Mecklenburgh, Irfan Rahman, Geoffrey J. Bellingan, Andrew Greening, Christopher Haslett, Edwin R. Chilvers

Journal:

Year:

1995

Language:

english

File:

PDF, 511 KB

english, 1995

23

Characterisation of secondary metabolites associated with neutrophil apoptosis

Alistair V.W. Nunn, Maria L. Barnard, Kishore Bhakoo, Joanna Murray, Edwin J. Chilvers, Jimmy D. Bell

Journal:

Year:

1996

Language:

english

File:

PDF, 413 KB

english, 1996

24

The role of HIF-1α in myeloid cell inflammation

Sarah R. Walmsley, Karen A. Cadwallader, Edwin R. Chilvers

Journal:

Trends in Immunology

Year:

2005

Language:

english

File:

PDF, 145 KB

english, 2005

25

Neutrophil kinetics in health and disease

Charlotte Summers, Sara M. Rankin, Alison M. Condliffe, Nanak Singh, A. Michael Peters, Edwin R. Chilvers

Journal:

Trends in Immunology

Year:

2010

Language:

english

File:

PDF, 260 KB

english, 2010

26

Priming of human neutrophil superoxide generation by tumour necrosis factor-α is signalled by enhanced phosphatidylinositol 3,4,5-trisphosphate but not inositol 1,4,5-trisphosphate accumulation

Alison M Condliffe, Phillip T Hawkins, Len R Stephens, Christopher Haslett, Edwin R Chilvers

Journal:

Year:

1998

Language:

english

File:

PDF, 155 KB

english, 1998

27

Modernising Medical Careers, Medical Training Application Service, and the Postgraduate Medical Education and Training Board: time for the emperors to don their clothes

Morris Brown, Nick Boon, Nick Brooks, Edwina Brown, John Camm, Mark Caulfield, Edwin Chilvers, John Gibson, George Griffin, Ashley Grossman, Alistair Hall, George Hart, Tony Heagerty, Philip Home, Hum

Journal:

Year:

2007

Language:

english

File:

PDF, 41 KB

english, 2007

28

Medical training in the UK: sleepwalking to disaster

Morris Brown, Nick Boon, Nick Brooks, John Camm, Paul Corris, Mark Caulfield, Edwin Chilvers, Pamela Ewan, John Gibson, George Griffin, Ashley Grossman, Alistair Hall, George Hart, Tony Heagerty, Hump

Journal:

Year:

2007

Language:

english

File:

PDF, 48 KB

english, 2007

29

Pharmacological manipulation of granulocyte apoptosis: potential therapeutic targets

Carol Ward, Ian Dransfield, Edwin R Chilvers, Chris Haslett, Adriano G Rossi

Journal:

Trends in Pharmacological Sciences

Year:

1999

Language:

english

File:

PDF, 210 KB

english, 1999

30

Acute lung injury results from failure of neutrophil de-priming: a new hypothesis

Nanak R. P. Singh, Andrew Johnson, A. Michael Peters, Judith Babar, Edwin R. Chilvers, Charlotte Summers

Journal:

European Journal of Clinical Investigation

Year:

2012

Language:

english

File:

PDF, 265 KB

english, 2012

31

Lack of effect of zaprinast on methacholine-induced contraction and inositol 1,4,5-trisphosphate accumulation in bovine tracheal smooth muscle

Edwin R. Chilvers, Mark A. Giembycz, R.A. John Challiss, Peter J. Barnes, Stefan R. Nahorski

Journal:

British Journal of Pharmacology

Year:

1991

Language:

english

File:

PDF, 1.60 MB

english, 1991

32

Induction of human neutrophil apoptosis by nitric oxide donors: evidence for a caspase-dependent, cyclic-GMP-independent, mechanism

Carol Ward, Terence H Wong, Joanna Murray, Irfan Rahman, Christopher Haslett, Edwin R Chilvers, Adriano G Rossi

Journal:

Biochemical Pharmacology

Year:

2000

Language:

english

File:

PDF, 538 KB

english, 2000

33

10.1038/9511

Sethi, Tariq, Rintoul, Robert C., Moore, Sarah M., MacKinnon, Alison C., Salter, Donald, Choo, Chin, Chilvers, Edwin R., Dransfield, Ian, Donnelly, Seamas C., Strieter, Robert, Haslett, Christopher

Journal:

Nature Medicine

Year:

1999

Language:

english

File:

PDF, 358 KB

english, 1999

34

Phosphoinositide 3-kinase: a critical signalling event in pulmonary cells

Alison M Condliffe, Karen A Cadwallader, Trevor R Walker, Robert C Rintoul, Andrew S Cowburn, Edwin R Chilvers

Journal:

Respiratory Research

Year:

2000

Language:

english

File:

PDF, 142 KB

english, 2000

35

Platelet-activating factor stimulates a rapid accumulation of inositol (1,4,5)trisphosphate in guinea pig eosinophils: Relationship to calcium mobilization and degranulation

Kroegel, Claus, Chilvers, Edwin R., Giembycz, Mark A., Challiss, R.A.John, Barnes, Peter J.

Journal:

Journal of Allergy and Clinical Immunology

Year:

1991

Language:

english

File:

PDF, 1.40 MB

english, 1991

36

Dissociation between β-adrenoceptor-mediated cyclic AMP accumulation and inhibition of histarnine-stimulated phosphoinositide metabolism in airways smooth muscle

Edwin R. Chilvers, Barbara J. Lynch, R.A.John Challiss

Journal:

Biochemical Pharmacology

Year:

1997

Language:

english

File:

PDF, 475 KB

english, 1997

37

Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function

Sarah R Walmsley, Edwin R Chilvers, Moira KB Whyte

Journal:

Arthritis Research & Therapy

Year:

2009

Language:

english

File:

PDF, 436 KB

english, 2009

38

The HIF/VHL Pathway

Walmsley, Sarah R., McGovern, Naomi N., Whyte, Moira K. B., Chilvers, Edwin R.

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2008

Language:

english

File:

PDF, 182 KB

english, 2008

39

Treating Idiopathic Pulmonary Fibrosis with the Addition of Co-Trimoxazole: An Economic Evaluation Alongside a Randomised Controlled Trial

Wilson, Edward C. F., Shulgina, Ludmila, Cahn, Anthony P., Chilvers, Edwin R., Parfrey, Helen, Clark, Allan B., Twentyman, Orion P., Wilson, Andrew M.

Journal:

PharmacoEconomics

Year:

2014

Language:

english

File:

PDF, 308 KB

english, 2014

40

Functional capacity of alveolar neutrophils in acute respiratory distress syndrome

Juss, Jatinder K, Herre, Jurgen, Amour, Augustin, Begg, Malcolm, House, David, Hessel, Edith M, Summers, Charlotte, Condliffe, Alison M, Chilvers, Edwin R

Journal:

Year:

2014

Language:

english

File:

PDF, 54 KB

english, 2014

41

Future treatment in patients with chronic obstructive pulmonary disease: To reverse or not to reverse steroid resistance—that is the question

Koenderman, Leo, Chilvers, Edwin R.

Journal:

Journal of Allergy and Clinical Immunology

Year:

2014

Language:

english

File:

PDF, 68 KB

english, 2014

42

Fat Embolism Syndrome with Purtscher’s Retinopathy

Scotton, William J., Kohler, Katherina, Babar, Judith, Russell-Hermanns, Dawn, Chilvers, Edwin R.

Journal:

American Journal of Respiratory and Critical Care Medicine

Year:

2013

Language:

english

File:

PDF, 236 KB

english, 2013

43

A novel RASA1 mutation causing capillary malformation-arteriovenous malformation (CM-AVM) presenting during pregnancy

Durrington, Hannah J., Firth, Helen V., Patient, Charlotte, Belham, Mark, Jayne, David, Burrows, Nigel, Morrell, Nicholas W., Chilvers, Edwin R.

Journal:

American Journal of Medical Genetics Part A

Year:

2013

Language:

english

File:

PDF, 4.32 MB

english, 2013

44

Mathematical modeling supports the presence of neutrophil depriming in vivo

Summers, Charlotte, Chilvers, Edwin R., Peters, A Michael

Journal:

Physiological Reports

Year:

2014

Language:

english

File:

PDF, 85 KB

english, 2014

45

Epidermal Deletion of HIF-2α Stimulates Wound Closure

Cowburn, Andrew S, Alexander, Laura E Crotty, Southwood, Mark, Nizet, Victor, Chilvers, Edwin R, Johnson, Randall S

Journal:

The Journal of Investigative Dermatology

Year:

2014

Language:

english

File:

PDF, 1.92 MB

english, 2014

46

Genome-wide transcription profiling in neutrophils in acute respiratory distress syndrome

Juss, JatinderK, Herre, Jurgen, Begg, Malcolm, Bradley, Glyn, Lennon, Mark, Amour, Augustin, House, David, Hessel, Edith M, Summers, Charlotte, Condliffe, Alison M, Chilvers, Edwin R

Journal:

Year:

2015

Language:

english

File:

PDF, 52 KB

english, 2015

47

Viscoelastic Properties of Differentiating Blood Cells Are Fate- and Function-Dependent

Ekpenyong, Andrew E., Whyte, Graeme, Chalut, Kevin, Pagliara, Stefano, Lautenschläger, Franziska, Fiddler, Christine, Paschke, Stephan, Keyser, Ulrich F., Chilvers, Edwin R., Guck, Jochen, Lam, Wilbur

Journal:

Year:

2012

Language:

english

File:

PDF, 609 KB

english, 2012

48

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California - ()] A37. LIPIDS IN LUNG DISEASES - Allergens As Immuno-Modulatory Proteins: The Cat Dander Protein FelD1 Enhances Toll-Like Receptor Activation By Lipid Ligands

Herre, Jurgen, Gronlund, Hans, Brookes, Heather, Murton, Ben, Opaleye, Niyi, Chilvers, Edwin, Lambrecht, Bart, Ganzinger, Krisitina, Klenerman, David, Fitzgerald, Katherine, Gay, Nick, Monie, Tom, Bry

Year:

2012

Language:

english

File:

PDF, 18 KB

english, 2012

49

Pulmonary retention of primed neutrophils: a novel protective host response, which is impaired in the acute respiratory distress syndrome

Summers, Charlotte, Singh, Nanak R, White, Jessica F, Mackenzie, Iain M, Johnston, Andrew, Solanki, Chandra, Balan, K K, Peters, A Michael, Chilvers, Edwin R

Journal:

Year:

2014

Language:

english

File:

PDF, 1.93 MB

english, 2014

50

Mechanotransduction in neutrophil activation and deactivation

Ekpenyong, Andrew E., Toepfner, Nicole, Chilvers, Edwin R., Guck, Jochen

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2015

Language:

english

File:

PDF, 902 KB

english, 2015

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